Carcinoma of the prostate and BPH cause many of the same symptoms. These two diseases frequently co-exist. Therefore, patients thought to have BPH should be examined prior to starting Hytrin therapy to rule out the presence of carcinoma of the prostate. Do not drink alcohol or use medicines that may cause drowsiness eg, sleep aids, muscle relaxers while you are using Hytrin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Medication. There are different kinds of medication used to treat BPH. Your doctor has prescribed Hytrin for you. See "What Hytrin does to treat BPH" below.
In a short term study Study 1 patients were randomized to either 2, 5 or 10 mg of Hytrin or placebo. In controlled trials, Hytrin tablets have been added to diuretics, and several beta-adrenergic blockers; no unexpected interactions were observed. Hytrin tablets have also been used in patients on a variety of concomitant therapies; while these were not formal interaction studies, no interactions were observed. The incidence of urinary tract infection was significantly lower in the patients receiving terazosin than in patients receiving placebo. An analysis of the incidence rate of hypotensive adverse events see PRECAUTIONS adjusted for the length of drug treatment has shown that the risk of the events is greatest during the initial seven days of treatment, but continues at all time intervals.
The dizziness, lightheadedness, or fainting is more likely to occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot. While you are taking this medicine, be careful to limit the amount of alcohol you drink. Also, use extra care during exercise or hot weather or if you must stand for long periods of time. Hytrin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Saunders E "The safety and efficacy of terazosin in the treatment of essential hypertension in blacks.
Hytrin may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hytrin with caution. If your symptoms do not improve or if they become worse, check with your doctor. Lowe FC "Safety assessment of terazosin in the treatment of patients with symptomatic benign prostatic hyperplasia - a combined analysis. Patients should be closely followed during initial administration in order to minimize the risk of severe hypotensive response.
Some MEDICINES MAY INTERACT with Hytrin. Please read this leaflet before you start taking Hytrin. Also, read it each time you get a new prescription. This is a summary and should NOT take the place of a full discussion with your doctor who has additional information about Hytrin. You and your doctor should discuss Hytrin and your condition before you start taking it and at your regular check-ups. Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment. Syncope has occurred in less than 1% of patients. Palpitations have been reported in 5% of patients, but are much less likely than with some other alpha-adrenergic blockers. Peripheral edema, cold extremities, and chest pain have been reported in up to 6%, 12%, and 5% of patients, respectively. Atrial fibrillation has been reported incidence not given. Caution should be observed when Hytrin tablets are administered concomitantly with other antihypertensive agents, especially the calcium channel blocker verapamil, to avoid the possibility of developing significant hypotension. When using Hytrin tablets and other antihypertensive agents concomitantly, dosage reduction and retitration of either agent may be necessary see PRECAUTIONS. Hypotension has been reported when Hytrin has been used with phosphodiesterase-5 PDE-5 inhibitors. The greater blood pressure effect associated with peak plasma concentrations first few hours after dosing appears somewhat more position-dependent greater in the erect position than the effect of terazosin at 24 hours and in the erect position there is also a 6-10 beat per minute increase in heart rate in the first few hours after dosing. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Highest dose 10 mg shown. In all three studies, both symptom scores and peak urine flow rates showed statistically significant improvement from baseline in patients treated with Hytrin from week 2 or the first clinic visit and throughout the study duration. Keep Hytrin and all medicines out of the reach of children.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Safety and effectiveness in children have not been determined. Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. Bottles of 100 NDC 0074-3324-13. Hytrin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. During cataract surgery, a variant of small pupil syndrome known as Intraoperative Floppy Iris Syndrome IFIS has been reported in association with alpha-1 blocker therapy see PRECAUTIONS. Statistically significant differences were not found in the verapamil level with and without terazosin. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. If Hytrin administration is discontinued for several days, therapy should be reinstituted using the initial dosing regimen. procardia
Hytrin is to be used only by the patient for whom it is prescribed. Do not share it with other people. Do not use it for other health conditions. Hypersensitivity reactions have been reported, including anaphylaxis and rashes. Some medical conditions may interact with Hytrin. Achari R, Laddu A "Terazosin: a new alpha adrenoceptor blocking drug. You will start with a 1 mg dose of Hytrin. Then the dose will be increased as your body gets used to the effect of the medication. Tell your doctor if you develop any new symptoms. AUC 0-24 increased 11% after the first verapamil dose and after 3 weeks of verapamil treatment it increased by 24% with associated increases in C max 25% and C min 32% means. While syncope is the most severe orthostatic effect of Hytrin tablets see WARNINGS other symptoms of lowered blood pressure, such as dizziness, lightheadedness and palpitations, were more common and occurred in some 28% of patients in clinical trials of hypertension. In BPH clinical trials, 21% of the patients experienced one or more of the following: dizziness, hypotension, postural hypotension, syncope, and vertigo. Patients with occupations in which such events represent potential problems should be treated with particular caution. Not all side effects for Hytrin may be reported. You should always consult a doctor or healthcare professional for medical advice. Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Tell your doctor or dentist that you take Hytrin before you receive any medical or dental care, emergency care, or surgery including eye surgery. Respiratory system side effects have been limited to nasal congestion in 2% to 12% of patients. Terazosin helps to lower blood pressure by relaxing blood vessels so that blood passes through them more easily. Gastrointestinal problems have been limited mainly to nausea in 5% of patients. cnil.info imitrex
The absence of mutagenicity in a battery of tests, of tumorigenicity of any cell type in the mouse carcinogenicity assay, of increased total tumor incidence in either species, and of proliferative adrenal lesions in female rats, suggests a male rat species-specific event. Numerous other diverse pharmaceutical and chemical compounds have also been associated with benign adrenal medullary tumors in male rats without supporting evidence for carcinogenicity in man. Terazosin helps relax the muscles in the prostate and the opening of the bladder. Hernandez RH, Angeligreaves M, Carvajal AR, Pajuelo JG, Padilla MCA, Armashernandez MJ "Terazosin: ex vivo and in vitro platelet aggregation effects in patients with arterial hypertension. However, terazosin will not help shrink the prostate. The prostate may continue to grow. This may cause the symptoms to become worse over time. Therefore, even though terazosin may lessen the problems caused by enlarged prostate now, surgery still may be needed in the future. Take Hytrin by mouth with or without food. At first, 1 milligram mg taken at bedtime. Then, 5 to 10 mg once a day. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Hytrin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Yellow No. 6, lactose, magnesium stearate, povidone and talc. Cohen J "Long-term efficacy and safety of terazosin. Hytrin was devoid of mutagenic potential when evaluated in vivo and in vitro the Ames test, in vivo cytogenetics, the dominant lethal test in mice, in vivo Chinese hamster chromosome aberration test and V79 forward mutation assay. The dose may be slowly increased to achieve the desired blood pressure response. The usual recommended dose range is 1 mg to 5 mg administered once a day; however, some patients may benefit from doses as high as 20 mg per day. Doses over 20 mg do not appear to provide further blood pressure effect and doses over 40 mg have not been studied. Blood pressure should be monitored at the end of the dosing interval to be sure control is maintained throughout the interval. It may also be helpful to measure blood pressure 2-3 hours after dosing to see if the maximum and minimum responses are similar, and to evaluate symptoms such as dizziness or palpitations which can result from excessive hypotensive response. If response is substantially diminished at 24 hours an increased dose or use of a twice daily regimen can be considered. If terazosin administration is discontinued for several days or longer, therapy should be reinstituted using the initial dosing regimen. In clinical trials, except for the initial dose, the dose was given in the morning. The presence of other medical problems may affect the use of this medicine. Patients should be advised about the possibility of priapism as a result of treatment with Hytrin and other similar medications. Patients should know that this reaction to Hytrin is extremely rare, but that if it is not brought to immediate medical attention, it can lead to permanent erectile dysfunction impotence. About Prostate Specific Antigen PSA. Your doctor may have done a blood test called PSA. Your doctor is aware that Hytrin does not affect PSA levels. You may want to ask your doctor more about this if you have had a PSA test done.
Itskovitz HD "Alpha-1-blockade for the treatment of hypertension - a megastudy of terazosin in 2214 clinical practice settings. Remember that terazosin will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. Guthrie R "Terazosin in the treatment of hypertension and symptomatic benign prostatic hyperplasia - a primary care trial. Use and dose must be determined by your doctor. Genitourinary complaints have rarely included impotence and priapism. Lepor H. Role of alpha-adrenergic blockers in the treatment of benign prostatic hypertrophy. Do NOT take more than the recommended dose without checking with your doctor. Hytrin helps relieve the symptoms of BPH. It does NOT change the size of the prostate, which may continue to grow. However, a larger prostate does not necessarily cause more or worse symptoms. Check with your pharmacist about how to dispose of unused medicine. Further dose response and dose duration studies are being carried out. Blood pressure should be measured at the end of the dose interval; if response is not satisfactory, patients may be tried on a larger dose or twice daily dosing regimen. The latter should also be considered if possibly blood pressure-related side effects, such as dizziness, palpitations, or orthostatic complaints, are seen within a few hours after dosing. Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter nonprescription medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. These adverse effects all occurred within 90 minutes of dosing. Ask your health care provider any questions you may have about how to use Hytrin. Testicular weights and morphology were unaffected by treatment. Musculoskeletal complaints of pain or cold extremities have been reported in up to 17% and 12% of patients, respectively. can i buy anafranil at target
If syncope occurs, the patient should be placed in a recumbent position and treated supportively as necessary. There is evidence that the orthostatic effect of Hytrin tablets is greater, even in chronic use, shortly after dosing. The risk of the events is greatest during the initial seven days of treatment, but continues at all time intervals. Doses of 10 mg once daily are generally required for the clinical response. Product Information. Hytrin terazosin. Bottles of 100 NDC 0074-3323-13. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Lepor H, Jones K, Williford W "The mechanism of adverse events associated with terazosin: An analysis of the Veterans Affairs cooperative study. Non-drug treatments are sometimes effective in controlling mild hypertension. The most important lifestyle changes to lower blood pressure are to lose weight, reduce salt, fat, and alcohol in the diet, quit smoking, and exercise regularly. However, many hypertensive patients require one or more ongoing medications to control their blood pressure. There are different kinds of medications used to treat hypertension. Your doctor has prescribed Hytrin for you. To help you remember to take your medicine, try to get into the habit of taking it at the same time each day. Lab tests, including blood pressure, may be performed while you use Hytrin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Similar adverse reaction rates were observed in placebo-controlled monotherapy trials. At first, 1 mg taken at bedtime. Then, 1 to 5 mg once a day. mirtazapine algorithm canada
If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. During controlled clinical trials, patients receiving terazosin monotherapy had a small but statistically significant decrease a 3% fall compared to placebo in total cholesterol and the combined low-density and very-low-density lipoprotein fractions. No significant changes were observed in high-density lipoprotein fraction and triglycerides compared to placebo. Ocular side effects including Intraoperative Floppy Iris Syndrome IFIS have been observed in some patients undergoing phacoemulsification cataract surgery while being treated with alpha-1 blockers. This may not be a complete list of all interactions that may occur. Ask your health care provider if Hytrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Nasal congestion and symptoms of sinusitis or dyspnea may be due to alpha-adrenergic blockade. The drug is highly bound to plasma proteins and binding is constant over the clinically observed concentration range. Approximately 10% of an orally administered dose is excreted as parent drug in the urine and approximately 20% is excreted in the feces. The remainder is eliminated as metabolites. Impaired renal function had no significant effect on the elimination of terazosin, and dosage adjustment of terazosin to compensate for the drug removal during hemodialysis approximately 10% does not appear to be necessary. Overall, approximately 40% of the administered dose is excreted in the urine and approximately 60% in the feces. The disposition of the compound in animals is qualitatively similar to that in man. Hytrin relaxes the tightness of a certain type of muscle in the prostate and at the opening of the bladder. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Hytrin Can Cause A Sudden Drop in Blood Pressure After the VERY FIRST DOSE. You may feel dizzy, faint, or "light-headed" particularly after you get up from bed or from a chair. This is more likely to occur after you've taken the first few doses, but can occur at any time while you are taking the drug. It can also occur if you stop taking the drug and then re-start treatment. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hytrin while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Hytrin, check with your doctor. Discuss any possible risks to your baby. Keep out of the reach of children. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Female rats were unaffected. To decrease the likelihood of syncope or excessive hypotension, treatment should always be initiated with a 1 mg dose of Hytrin tablets, given at bedtime. The 2 mg, 5 mg and 10 mg tablets are not indicated as initial therapy. Dosage should then be increased slowly, according to recommendations in the Dosage and Administration section and additional antihypertensive agents should be added with caution. The patient should be cautioned to avoid situations, such as driving or hazardous tasks, where injury could result should syncope occur during initiation of therapy.
Sperzel WD, Glassman HN, Jordan DC, Luther RR "Overall safety of terazosin as an antihypertensive agent. Oddly enough, though, I think this has led to another problem. Includes weakness, tiredness, lassitude and fatigue. Do not stop taking any medications without consulting your healthcare provider. Hematologic side effects have included thrombocytopenia. All medicines may cause side effects, but many people have no, or minor, side effects. In this long-term trial, both symptom scores and peak urinary flow rates showed statistically significant improvement suggesting a relaxation of smooth muscle cells. valacyclovir tablets order online pharmacy
Patients should also be told that drowsiness or somnolence can occur with Hytrin tablets, requiring caution in people who must drive or operate heavy machinery. Elhilali MM, Ramsey EW, Barkin J, Casey RW, Boake RC, Beland G, Fradet Y, Trachtenberg J, Orovan WL, Schick E, Klotz LH "A multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of terazosin in the treatment of benign prostatic hyperplasia. Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder. As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems in urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely. The information contained in the Truven Health Micromedex products as delivered by Drugs. If Hytrin is helping you, you should notice an effect on your particular symptoms in 2 to 4 weeks of starting to take the medication. In a long-term, open-label, non-placebo controlled clinical trial, 181 men were followed for 2 years and 58 of these men were followed for 30 months. The adverse events were usually transient and mild or moderate in intensity, but sometimes were serious enough to interrupt treatment. In the placebo-controlled clinical trials, the rates of premature termination due to adverse events were not statistically different between the placebo and terazosin groups. VERY weak urine stream. I find that, as long as I take it on schedule, and don't forget doses, my urine stream has improved a great deal, almost to the level of what I considered normal. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Both differences were statistically significant. Terazosin hydrochloride is a white, crystalline substance, freely soluble in water and isotonic saline and has a molecular weight of 459. Oddly enough, though, I think this has led to another problem. I've developed nocturia and often have to get up from bed to urinate. Now that my flow is strengthened due to this med, I often have incontinence if I'm in a deep sleep and the urge doesn't wake me up in time. Not sure of this, of course, but it seems logical. sominex
Mersey JH "Long-term experience with terazosin for treatment of mild to moderate hypertension. Post-marketing experience indicates that in rare instances patients may develop allergic reactions, including anaphylaxis, following administration of terazosin hydrochloride. There have been reports of priapism and thrombocytopenia during post-marketing surveillance. Atrial fibrillation has been reported. Terazosin is available only with your doctor's prescription. Increased fetal resorptions, decreased fetal weight and an increased number of supernumerary ribs were observed in offspring of rabbits dosed with 60 times the maximum recommended human dose. These findings in both species were most likely secondary to maternal toxicity. There are no adequate and well-controlled studies in pregnant women and the safety of terazosin in pregnancy has not been established. Hytrin is not recommended during pregnancy unless the potential benefit justifies the potential risk to the mother and fetus. Patients should be made aware of the possibility of syncopal and orthostatic symptoms, especially at the initiation of therapy, and to avoid driving or hazardous tasks for 12 hours after the first dose, after a dosage increase and after interruption of therapy when treatment is resumed. They should be cautioned to avoid situations where injury could result should syncope occur during initiation of Hytrin therapy. They should also be advised of the need to sit or lie down when symptoms of lowered blood pressure occur, although these symptoms are not always orthostatic, and to be careful when rising from a sitting or lying position. If dizziness, lightheadedness, or palpitations are bothersome they should be reported to the physician, so that dose adjustment can be considered. Only 4% of 354 patients from a multicenter trial complained of general abdominal pain or diarrhea within the first 90 days of therapy. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Hytrin works by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure. What is BPH? Hytrin was not teratogenic in either rats or rabbits when administered at oral doses up to 280 and 60 times, respectively, the maximum recommended human dose. This initial dosing regimen should be strictly observed to minimize the potential for severe hypotensive effects. Remember that terazosin will not shrink the size of your prostate but it does help to relieve the symptoms. In animals, terazosin causes a decrease in blood pressure by decreasing total peripheral vascular resistance. The vasodilatory hypotensive action of terazosin appears to be produced mainly by blockade of alpha-1 adrenoceptors. Terazosin decreases blood pressure gradually within 15 minutes following oral administration. Lepor H "Long-term efficacy and safety of terazosin in patients with benign prostatic hyperplasia.
Dermatologic side effects of skin rash have been reported rarely. Lichenoid drug eruption has been associated with terazosin the active ingredient contained in Hytrin therapy. Analysis of the effect of Hytrin on individual urinary symptoms demonstrated that compared to placebo, Hytrin significantly improved the symptoms of hesitancy, intermittency, impairment in size and force of urinary stream, sensation of incomplete emptying, terminal dribbling, daytime frequency and nocturia. Metabolic side effects have included decreases in serum triglycerides and VLDL cholesterol, and increases in HDL cholesterol. Terazosin the active ingredient contained in Hytrin may counterbalance deleterious effects on the lipid profile associated with thiazide diuretics, making it a reasonable drug to use in combination with these agents. Analysis of clinical laboratory data following administration of terazosin suggested the possibility of hemodilution based on decreases in hematocrit, hemoglobin, white blood cells, total protein and albumin. Decreases in hematocrit and total protein have been observed with alpha-blockade and are attributed to hemodilution. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Do not keep outdated medicine or medicine no longer needed. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal. Some of the side effects that can occur with terazosin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. There was a tendency for patients to gain weight during terazosin therapy. Store Hytrin at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hytrin out of the reach of children and away from pets. Extremely rarely, Hytrin and similar medications have caused painful erection of the penis, sustained for hours and unrelieved by sexual intercourse or masturbation. This condition is serious, and if untreated it can be followed by permanent inability to have an erection. If you have a prolonged abnormal erection, call your doctor or go to an emergency room as soon as possible. Because of this effect, your doctor may have told you to take Hytrin at bedtime. If you take Hytrin at bedtime but need to get up from bed to go to the bathroom, get up slowly and cautiously until you are sure how the medicine affects you. It is also important to get up slowly from a chair or bed at any time until you learn how you react to Hytrin. You should not drive or do any hazardous tasks until you are used to the effects of the medication. If you begin to feel dizzy, sit or lie down until you feel better. This information should not be used to decide whether or not to take Hytrin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Hytrin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Hytrin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Hytrin. The dose of Hytrin and the dose interval 12 or 24 hours should be adjusted according to the patient's individual blood pressure response. aricept
Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness. Rarely, probably less than once in every several thousand patients terazosin and other α 1-antagonists have been associated with priapism painful penile erection, sustained for hours and unrelieved by sexual intercourse or masturbation. Two or three dozen cases have been reported. Because this condition can lead to permanent impotence if not promptly treated, patients must be advised about the seriousness of the condition see PRECAUTIONS - Information for Patients. The adverse reactions were usually mild or moderate in intensity but sometimes were serious enough to interrupt treatment. Cohen J "Long-term efficacy and safety of terazosin alone and in combination with other antihypertensive agents. If high blood pressure is not treated, over time, the increased pressure can damage blood vessels or it can cause the heart to work too hard and may decrease the flow of blood to the heart, brain, and kidneys. As a result, these organs may become damaged and not function correctly. If high blood pressure is controlled, this damage is less likely to happen. Additional adverse reactions have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. The incidence of treatment-emergent adverse events has been ascertained from clinical trials conducted worldwide. All adverse events reported during these trials were recorded as adverse reactions. The incidence rates presented below are based on combined data from six placebo-controlled trials involving once-a-day administration of terazosin at doses ranging from 1 to 20 mg. Table 1 summarizes those adverse events reported for patients in these trials when the incidence rate in the terazosin group was at least 1% and was greater than that for the placebo group, or where the reaction is of clinical interest. You should see an effect on your symptoms in 2 to 4 weeks. So, you will need to continue seeing your doctor to check your progress regarding your BPH and to monitor your blood pressure in addition to your other regular check-ups. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
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The rash was accompanied by mild fever, asthenia, and intense pruritus. The patient was on no other medications. Hematologic and histopathologic studies suggested a drug reaction. Terazosin was discontinued. Two weeks following oral methylprednisolone 40 mg daily and emollients, symptoms had resolved completely. Nervous system side effects, such as dizziness 5% to 30% of patients and blurred vision 2% of patients may be related to hypotension. Headaches 2% to 10% asthenia 8% and somnolence 6% have occurred following long-term use. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Additional adverse events have been reported, but these are, in general, not distinguishable from symptoms that might have occurred in the absence of exposure to terazosin. The safety profile of patients treated in the long-term open-label study was similar to that observed in the controlled studies. Limited measurements of peak response 2-3 hours after dosing during chronic terazosin administration indicate that it is greater than about twice the trough 24 hour response, suggesting some attenuation of response at 24 hours, presumably due to a fall in blood terazosin concentrations at the end of the dose interval.
In addition to the use of the medicine your doctor has prescribed, treatment for your high blood pressure may include weight control and care in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.
Hytrin is used to treat high blood pressure hypertension. Hytrin is also used to treat benign prostatic hyperplasia BPH in men. This leaflet describes Hytrin as a treatment for hypertension or BPH. What Is Hypertension High Blood Pressure? There does not appear to be a benefit of stopping alpha-1 blocker therapy prior to cataract surgery. Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.